Stimson’s Blockchain in Practice program tests the potential for Distributed Ledger Technology (DLT) platforms to increase transparency and security in nuclear safeguards, nuclear security, and the trade of dual-use materials. International security regimes face the common challenge of ensuring the integrity of data, information flow, and traceability. DLT offers a novel solution to this challenge and Stimson is at the forefront of studying and socializing the technology among stakeholders and testing it in real-life scenarios.